SELT Antibody (N-term) [APR06158G]

SELT Antibody (N-term) [APR06158G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SELT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-75 amino acids from the N-terminal region of human SELT.

Cellular Localisation: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q1H5H1}; Single-pass membrane protein

Molecular Weight: 22324

Clone: Polyclonal

Gene Name: SELENOT {ECO:0000303|PubMed:27645994, ECO:0000312|HGNC:HGNC:18136}

Gene ID: 51714

Function: Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity) . Protects dopaminergic neurons against oxidative stress ans cell death (PubMed:26866473) . Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity) . Plays a role in fibroblast anchorage and redox regulation (By similarity) . In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity) . In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP- induced insulin secretion (By similarity) .

Summary: Tissue Location: Ubiquitous. Highly expressed in the endocrine pancreas.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC

Dilution: WB--1:1000 FC--1:10~50

Synonyms: Selenoprotein T, SelT, SELT