SEMA3E Antibody (C-term) [APR13240G]

SEMA3E Antibody (C-term) [APR13240G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This SEMA3E antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 737-766 amino acids from the C-terminal region of human SEMA3E.

Cellular Localisation: Secreted.

Molecular Weight: 89543

Clone: Polyclonal

Gene Name: Sema3e

Gene ID: 20349

Function: Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation.

Summary: Tissue Location: Detected in neurons in the thalamus. Detected in embryonic vasculature. Developing lungs, developing skeletal elements and ventral horns of the developing neural tube. Correlates positively with tumor progression.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Semaphorin-3E, Semaphorin-H, Sema H, Sema3e, Semah, Semh