LBD
SEMA7A Antibody (C-term) [APR33367G]
- SKU:
- LBD-APR33367G
- Availability:
- Usually ships in 5 working days
Description
SEMA7A Antibody (C-term) [APR33367G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This SEMA7A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 521-555 amino acids from the C-terminal region of human SEMA7A.
Cellular Localisation: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Note=Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes
Molecular Weight: 74824
Clone: Polyclonal
Gene Name: SEMA7A
Gene ID: 8482
Function: Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
Summary: Tissue Location: Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level) . Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney.
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:2000
Synonyms: Semaphorin-7A, CDw108, JMH blood group antigen, John-Milton-Hargen human blood group Ag, Semaphorin-K1, Sema K1, Semaphorin-L, Sema L, CD108, SEMA7A, CD108, SEMAL