SEPT8 Antibody (C-term) [APR04144G]

SEPT8 Antibody (C-term) [APR04144G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SEPT8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-436 amino acids from the C-terminal region of human SEPT8.

Cellular Localisation: Cytoplasm {ECO:0000250|UniProtKB:B0BNF1}. Cytoplasm, cytoskeleton. Cell junction, synapse {ECO:0000250|UniProtKB:B0BNF1}. Cell projection, axon {ECO:0000250|UniProtKB:B0BNF1}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:B0BNF1}. Cell junction, synapse, presynapse {ECO:0000250|UniProtKB:B0BNF1} Note=Expressed in axons of immature neurons, localizes to synapses in mature neurons (By similarity) . In platelets, found in areas surrounding alpha-granules (PubMed:15116257) {ECO:0000250|UniProtKB:B0BNF1, ECO:0000269|PubMed:15116257}

Molecular Weight: 55756

Clone: Polyclonal

Gene Name: SEPTIN8 (HGNC:16511)

Gene ID: 23176

Function: Filament-forming cytoskeletal GTPase (By similarity) . May play a role in platelet secretion (PubMed:15116257) . Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity) .

Summary: Tissue Location: Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Septin-8, SEPT8, KIAA0202