Serpin B6 polyclonal Antibody | BS71379

Serpin B6 polyclonal Antibody | BS71379 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB

Application Range: WB 1:500 - 1:2000

Background: SerpinB6, also known as protease inhibitor 6 (PI-6) in human and Spi3 in mouse, is a serine protease inhibitor with both antitrypsin and antichymotrypsin activity. Although most serpins are secreted glycoproteins that regulate extracellular proteases, SerpinB6 lacks classical nuclear localization, exhibiting primarily cytoplasmic distribution, and is not secreted by conventional methods. SerpinB6 is present in most tissues in capillary endothelial cells, platelets, epithelial cells, monocytes and granulocytes. SerpinB6 binds the arginine-selective protease human kallikrein 2 (hK2) as well as the monocyte and granulocyte azurophilic granule protease cathepsin G. In mouse, there are three SerpinB6 genes, namely SerpinB6a, SerpinB6b and SerpinB6c.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Serpin B6 polyclonal Antibody detects endogenous levels of Serpin B6 protein.

Molecular Weight: ~ 43 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Serpin B6; Cytoplasmic antiproteinase; CAP; Peptidase inhibitor 6; PI-6; Placental thrombin inhibitor; SERPINB6; PI6; PTI

Immunogen: Recombinant protein of human SERPINB6.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: