SERPINE1 Antibody (C-term) [AMR09882G]

SERPINE1 Antibody (C-term) [AMR09882G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SERPINE1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 323-357 amino acids from the C-terminal region of human SERPINE1.

Cellular Localisation: Secreted.

Molecular Weight: 45060

Clone: Polyclonal

Gene Name: SERPINE1

Gene ID: 5054

Function: Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774) . Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU) . As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461) . As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705) . Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821) . It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027) . It is involved in cellular and replicative senescence (PubMed:16862142) . Plays a role in alveolar type 2 cells senescence in the lung (By similarity) . Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084) .

Summary: Tissue Location: Expressed in endothelial cells (PubMed:2430793, PubMed:3097076) . Found in plasma, platelets, and hepatoma and fibrosarcoma cells.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Plasminogen activator inhibitor 1, PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1, SERPINE1, PAI1, PLANH1