Sestrin-3 Antibody (Center Y335) [APR07009G]

Sestrin-3 Antibody (Center Y335) [APR07009G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This Sestrin-3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 320-347 amino acids from the Central region of human Sestrin-3.

Cellular Localisation: Cytoplasm.

Molecular Weight: 57291

Clone: Polyclonal

Gene Name: SESN3 (HGNC:23060)

Gene ID: 143686

Function: May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562) . May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity) . This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity) . May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity) .

Summary: Tissue Location: Widely expressed..

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:2000 WB--1:1000 IHC-P--1:100~500

Synonyms: Sestrin-3, SESN3, SEST3