LBD
Sestrin-3 Antibody (Center Y335) [APR07009G]
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- LBD-APR07009G
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Description
Sestrin-3 Antibody (Center Y335) [APR07009G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This Sestrin-3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 320-347 amino acids from the Central region of human Sestrin-3.
Cellular Localisation: Cytoplasm.
Molecular Weight: 57291
Clone: Polyclonal
Gene Name: SESN3 (HGNC:23060)
Gene ID: 143686
Function: May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562) . May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity) . This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity) . May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity) .
Summary: Tissue Location: Widely expressed..
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P
Dilution: WB--1:2000 WB--1:1000 IHC-P--1:100~500
Synonyms: Sestrin-3, SESN3, SEST3