SET polyclonal Antibody | BS91227

SET polyclonal Antibody | BS91227 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC IF IHC IP FC

Application Range: WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 IP:1:10-1:50 FC:1:50-1:100

Background: Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL) -induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: SET polyclonal Antibody detects endogenous levels of SET protein.

Molecular Weight: 37 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: IGAAD, I-2PP2A, TAF-I, SET, 2PP2A, HLA DR associated protein II, HLA-DR-associated protein II, I 2PP2A, I-2PP2A, I2PP2A, IGAAD, Inhibitor of granzyme A activated DNase, Inhibitor of granzyme A-activated DNase, Inhibitor of GzmA-activated DNase, inhibitor-2 of protein phosphatase-2A, IPP2A2, PHAPII, Phosphatase 2A inhibitor I2PP2A, protein phosphatase type 2A inhibitor, Protein SET, Set, SET nuclear oncogene, SET translocation, SET translocation (myeloid leukemia-associated), SET, TAF I, TAF IBETA, TAF-I, TAFI, Template activating factor I, Template-activating factor I, Template-Activating Factor-I, chromatin remodelling factor,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: