SETD6 polyclonal Antibody | BS8794

SETD6 polyclonal Antibody | BS8794 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB 1:500 - 1:2000

Background: SETD6 (SET domain-containing protein 6) is a 473 amino acid protein that belongs to the SETD6 family. Containing one SET domain, SETD6 is structurally similar to the Rubisco large subunit methyltransferase. SETD6 is a proteinlysine N-methyltransferase that specifically monomethylates “Lys-310” of the NFκB p65 subunit of NFκB complex, leading to down-regulate NFκB transcription factor activity. SETD6-mediated methylation renders NFκB p65 inert and attenuates NFκB p65-driven transcriptional programs, including inflammatory responses in primary immune cells. The SETD6-initiated lysine-methylation signaling cascade acts to restrain activation of NFκB-mediated inflammatory responses in diverse cell types.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SETD6 polyclonal Antibody detects endogenous levels of SETD6 protein.

Molecular Weight: ~ 53 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: N-lysine methyltransferase SETD6; SET domain-containing protein 6; SETD6

Immunogen: Recombinant full length Human SETD6.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: