SF1670 | 2774

SF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor (IC₅₀ = 2 µM). It specifically binds to the active site of PTEN. At nanomolar concentrations it increases cellular phosphatidylinositol 3,4,5-trisphosphate (PIP3) levels, phosphorylation of Akt, and glucose uptake in adipocytes. Pretreatment with SF1670 has been used to enhance PIP3 signaling in transplanted neutrophils, augmenting their function at sites of infection in neutropenic recipient mice.

SF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor (IC₅₀ = 2 µM). It specifically binds to the active site of PTEN. At nanomolar concentrations it increases cellular phosphatidylinositol 3,4,5-trisphosphate (PIP3) levels, phosphorylation of Akt, and glucose uptake in adipocytes. Pretreatment with SF1670 has been used to enhance PIP3 signaling in transplanted neutrophils, augmenting their function at sites of infection in neutropenic recipient mice.

2774 | SF1670 DataSheet

Alternate Name/Synonyms: N-​(9,​10-​dihydro-​9,​10-​dioxo-​2-​phenanthrenyl)-​2,​2-​dimethyl-​propanamide

Appearance: Light pink to dark purple solid

Formulation: N/A

CAS Number: 345630-40-2

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₇NO₃

Molecular Weight: 307.34

Cell-Permeable?: Y

Purity: ≥98%

Solubilities: DMSO (~ 10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective PTEN inhibitor

MDL Number: N/A

PubChem CID: 9926586

SMILES: CC(C)(C)C(=O)NC1=CC2=C(C=C1)C3=CC=CC=C3C(=O)C2=O

InChi: InChI=1S/C19H17NO3/c1-19(2,3)18(23)20-11-8-9-13-12-6-4-5-7-14(12)16(21)17(22)15(13)10-11/h4-10H,1-3H3,(H,20,23)

InChi Key: VZQDDSYKVYARDW-UHFFFAOYSA-N