SF2 polyclonal Antibody | BS91228

SF2 polyclonal Antibody | BS91228 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC IF IHC FC

Application Range: WB:1:500-1:1,000 ICC:1:50 IHC:1:50-1:200 FC:1:50-1:100

Background: Pre-mRNA splicing enhancer elements are short RNA sequences capable of activating weak splice sites in nearby introns that are required for accurate splice site recognition and the control of alternative splicing. Splicing enhancer elements contain specific binding sites for serine/arginine (SR) -rich splicing factors, which include SC35, 9G8, SRp20, and SF2/ASF. The family of SR factors all contain one or more RNA recognition motifs (RRM) and an arginine/ serine (RS) -rich domain. They are not only essential for constitutive splicing but also regulate splicing in a concentration-dependent manner by influencing the selection of alternative splice sites. The majority of SR proteins, including SC35 and SRp40, are confined to the nucleus, while SF2/ASF, SRp20, and 9G8 are continuously shuttled between the nucleus and the cytoplasm and contribute to mRNA transport. The activity of SR proteins in regulated splicing is antagonized by members of the hnRNP A/B family of proteins, which induce drastic shifts in the selection of splicing sites.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: SF2 polyclonal Antibody detects endogenous levels of SF2 protein.

Molecular Weight: N/A

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ASF-1, SRSF1, ASF, SF2, SF2P33, SFRS1, OK/SW-cl.3, Alternative splicing factor 1, Alternative-splicing factor 1, arginine/serine-rich 1, ASF 1, ASF, ASF-1, ASF1, FLJ53078, MGC5228, P33 subunit, Pre mRNA splicing factor SF2 P33 subunit, pre-mRNA-splicing factor SF2, Serine/arginine-rich splicing factor 1, SF2, SF2P33, SFRS1, Splicing factor 2 alternate splicing factor, Splicing factor 2, Splicing factor, Splicing factor arginine/serine rich 1, SR Splicing factor 1, SRp30a, srsf1, SRSF1,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: