SFPQ polyclonal Antibody | BS70274

SFPQ polyclonal Antibody | BS70274 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC IF

Application Range: WB : 1:500 - 1:1000 IHC /IF: 1:50 - 1:200

Background: SFPQ, also named PSF, encodes a nuclear factor implicated in the splicing and regulation of gene expression. SFPQ probably forms a heteromer with NONO and participates in DNA pairing and DNA break repair program. Very recently SFPQ was identified as a downstream target of tau, complete nuclear depletion and cytoplasmic accumulation of SFPQ were shown in the neurons and astrocytes of brains with Alzheimer's disease (AD), more strikingly, reduced SFPQ levels may progress together with tau pathology, these observation strongly suggests the important role of SFPQ pathology in neurodegenerative diseases including AD. SFPQ protein may appears as 47 kDa, 52 kDa or 100 kDa molecules in various cell types. Catalog# 15585-1-AP is a rabbit polyclonal Antibody raised against the N-terminal of human SFPQ.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SFPQ polyclonal Antibody detects endogenous levels of SFPQ protein.

Molecular Weight: ~ 115 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: SFPQ;POMP100;PSF ;

Immunogen: Recombinant protein of human SFPQ.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: