SFPQ polyclonal Antibody | BS91231

SFPQ polyclonal Antibody | BS91231 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB IHC ICC IF

Application Range: WB:1:500-1:2,000 IHC:1:50-1:200 ICC:1:10-1:50

Background: DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: SFPQ polyclonal Antibody detects endogenous levels of SFPQ protein.

Molecular Weight: 100 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: hPOMp100, PSF, PTB-associated-splicing factor, SFPQ, 100 kDa DNA pairing protein, 100 kDa DNA-pairing protein, 100 kDa subunit, DNA binding p52/p100 complex 100 kDa subunit, DNA-binding p52/p100 complex, hPOMp100, Polypyrimidine tract binding protein associated splicing factor, Polypyrimidine tract-binding protein-associated-splicing factor, POMP100, PPP1R140, proline- and glutamine-rich, Protein phosphatase 1 regulatory subunit 140, PSF, PTB associated splicing factor, PTB-associated-splicing factor, Sfpq, SFPQ, Splicing factor, Splicing factor proline and glutamine rich, Splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated), Splicing factor proline/glutamine rich,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: Wntβ catenin signaling，