SFRS3 polyclonal Antibody | BS91235

SFRS3 polyclonal Antibody | BS91235 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB IHC ICC

Application Range: WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:100-1:500

Background: Splicing factor that specifically promotes exon-inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A) -containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing. Also functions as export adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway) ; enhances NXF1-NXT1 RNA-binding activity. Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244) . RNA-binding is semi-sequence specific.

Storage & Stability: Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.

Specificity: SFRS3 polyclonal Antibody detects endogenous levels of SFRS3 protein.

Molecular Weight: 19 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: SRSF3, SFRS3, SRP20, arginine/serine-rich 3, Pre mRNA splicing factor SRP20, Pre-mRNA-splicing factor SRP20, Serine/arginine-rich splicing factor 3, Splicing factor, Splicing factor arginine/serine rich 20 kD, Splicing factor arginine/serine rich 3, SRp20, SRSF3, SRSF3, X16 Antibody

Immunogen: Full length recombinant protein.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Protein A purified.

Pathway: MTOR signaling,