SGC0946 | 2448

A potent and selective DOT1L inhibitor (IC₅₀ = 0. 3 nM in a radioactive enzyme assay); >100-fold selective for other histone methyltransferases (HMTs). SGC0946 also potently reduces H3K79 dimethylation with cellular IC₅₀ of 2.6 nM in A431 cells, and 8.8 nM in MCF10A cells.

SGC0946 is a potent and selective DOT1L inhibitor (IC₅₀ = 0. 3 nM in a radioactive enzyme assay); >100-fold selective for other histone methyltransferases (HMTs).

2448 | SGC0946 DataSheet

Alternate Name/Synonyms: 1-[3-[[[(2R,3S,4R,5R)-5-(4-Amino-5-​bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydro​xytetrahydrofuran-2-yl]methyl](isopropyl)amino]pro​pyl]-3-[4-(2,2-dimethylethyl)phenyl]urea

Appearance: White solid

Formulation: N/A

CAS Number: 1561178-17-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₄₀BrN₇O₄

Molecular Weight: 618.57

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (> 50 mg/ml) or EtOH (>50 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent DOT1L inhibitor

MDL Number: N/A

PubChem CID: 71729976

SMILES: CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC2C(C(C(O2)N3C(=CC4=C3N=CN=C4N)Br)O)O

InChi: InChI=1S/C28H40BrN7O4/c1-16(2)35(12-6-11-31-27(39)34-18-9-7-17(8-10-18)28(3,4)5)14-20-22(37)23(38)26(40-20)36-21(29)13-19-24(30)32-15-33-25(19)36/h7-10,13,15-16,20,22-23,26,37-38H,6,11-12,14H2,1-5H3,(H2,30,32,33)(H2,31,34,39)/t20-,22-,23-,26-/m1/s1

InChi Key: CNTIACSNJOOHEX-HUBRGWSESA-N