Description
SGI-1027 is a selective DNA methyltransferase (DNMT) inhibitor. Inhibits DNMT1, DNMT3A, and DNMT3B with IC₅₀ values of 6, 8, and 7.5 µM, respectively. Treatment of different cancer cell lines with SGI-1027 results in selective degradation of DNMT1 with minimal or no effects on DNMT3A and DNMT3B
SGI-1027 is a selective DNA methyltransferase (DNMT) inhibitor. Inhibits DNMT1, DNMT3A, and DNMT3B with IC₅₀ values of 6, 8, and 7.5 µM, respectively. Treatment of different cancer cell lines with SGI-1027 results in selective degradation of DNMT1 with minimal or no effects on DNMT3A and DNMT3B
Alternate Name/Synonyms: N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide
Appearance: Off-white solid
Formulation: N/A
CAS Number: 1020149-73-8
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₇H₂₃N₇O
Molecular Weight: 461.52
Cell-Permeable?: Yes
Purity: ³98%
Solubilities: DMSO (~20 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A selective DNA methyltransferase (DNMT) inhibitor
MDL Number: N/A
PubChem CID: 24858111
SMILES: CC1=CC(=NC(=N1)N)NC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)NC4=CC=NC5=CC=CC=C54
InChi: InChI=1S/C27H23N7O/c1-17-16-25(34-27(28)30-17)32-20-10-12-21(13-11-20)33-26(35)18-6-8-19(9-7-18)31-24-14-15-29-23-5-3-2-4-22(23)24/h2-16H,1H3,(H,29,31)(H,33,35)(H3,28,30,32,34)
InChi Key: QSYLKMKIVWJAAK-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |