SGI-1027 | 2726

SGI-1027 is a selective DNA methyltransferase (DNMT) inhibitor. Inhibits DNMT1, DNMT3A, and DNMT3B with IC₅₀ values of 6, 8, and 7.5 µM, respectively. Treatment of different cancer cell lines with SGI-1027 results in selective degradation of DNMT1 with minimal or no effects on DNMT3A and DNMT3B

SGI-1027 is a selective DNA methyltransferase (DNMT) inhibitor. Inhibits DNMT1, DNMT3A, and DNMT3B with IC₅₀ values of 6, 8, and 7.5 µM, respectively. Treatment of different cancer cell lines with SGI-1027 results in selective degradation of DNMT1 with minimal or no effects on DNMT3A and DNMT3B

2726 | SGI-1027 DataSheet

Alternate Name/Synonyms: N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide

Appearance: Off-white solid

Formulation: N/A

CAS Number: 1020149-73-8

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₂₃N₇O

Molecular Weight: 461.52

Cell-Permeable?: Yes

Purity: ³98%

Solubilities: DMSO (~20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective DNA methyltransferase (DNMT) inhibitor

MDL Number: N/A

PubChem CID: 24858111

SMILES: CC1=CC(=NC(=N1)N)NC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)NC4=CC=NC5=CC=CC=C54

InChi: InChI=1S/C27H23N7O/c1-17-16-25(34-27(28)30-17)32-20-10-12-21(13-11-20)33-26(35)18-6-8-19(9-7-18)31-24-14-15-29-23-5-3-2-4-22(23)24/h2-16H,1H3,(H,29,31)(H,33,35)(H3,28,30,32,34)

InChi Key: QSYLKMKIVWJAAK-UHFFFAOYSA-N