749
SH-PTP2 Polyclonal Antibody | ABP52441
- SKU:
- 749-ABP52441
- Availability:
- Usually ships in 5 working days
Description
SH-PTP2 Polyclonal Antibody | ABP52441 | Gentaur UK, US & Europe Distribution
Immunogen: Synthesized peptide derived from human SH-PTP2 around the non-phosphorylation site of Y542
Product Category: Protein
Application: Protein General Reagents
Product Type: Primary Antibody
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB, IHC-P, ELISA
Application Note: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:40000) . Not yet tested in other applications.
Clonality: Polyclonal
Isotype: Rabbit IgG
Formulation: Liquid solution
Kit Component: N/A
Concentration: 1 mg/ml
Storage Buffer: PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage Instructions: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Condition: Gel pack with blue ice.
Background: Tyrosine-protein phosphatase non-receptor type 11 encoded by PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.
Alternative Names: PTPN11; PTP2C; SHPTP2; Tyrosine-protein phosphatase non-receptor type 11; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3
Precaution: The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.