552
Sheep Anti-Human Apolipoprotein (a) Neat Antiserum | ABMC-S02
- SKU:
- 552-S02-GEN
- Availability:
- IN STOCK
Description
Sheep Anti-Human Apolipoprotein (a) Neat Antiserum |S02
| Host Species: | Sheep |
| Antigen: | Human Apolipoprotein (a) |
| Specificity | Specifically binds to human Lp (a) and apo (a). No cross-reaction to apo B-100/48; mino to plasminogen (Cross-reactivity to plasminogen was removed by passing plasminogen-Sepharose™ affinity column). Dilution for immunoblot and ELISA range: 1,000 to 200,000. |
| Use: | The antibody can be used for detection of Lp(a) and apo (a) in human plasma and lipoproteins, using immunoassays or immunoblots. |
| Storage: | -20°C for long-term storage, 4°C for short- term storage. Aliquot to avoid repeated freezing and thawing. |
IMPORTANCE
The Lipoprotein (a) [Lp(a)] structure is similar to that of low density lipoprotein (LDL), regarding size and lipid composition of the particles and the presence of apolipoprotein B-100 (apo B-100). In addition to apo B-100, Lp(a) has a second protein, apolipoprotein (a) [apo (a)], which the molecular weight of that glycoprotein varies widely from 400 to 700 kDa. (Maranhão et al., 2013)
Previous research has shown that apo (a) has a similar structure with plasminogen and contains a serine protease domain and two types of plasminogen-like kringle domains. (McLean et al., 1987) The plasma concentration of human lipoprotein[a], Lp[a], is highly correlated with coronary artery disease. (Gaubatz et al., 1990)
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