SHISA6 Antibody (N-term) [APR13308G]

SHISA6 Antibody (N-term) [APR13308G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SHISA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-109 amino acids from the N-terminal region of human SHISA6.

Cellular Localisation: Membrane; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q3UH99}. Cell junction, synapse, postsynaptic density {ECO:0000250|UniProtKB:Q3UH99}

Molecular Weight: 55764

Clone: Polyclonal

Gene Name: SHISA6 (HGNC:34491)

Gene ID: 388336

Function: Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway.

Summary: Tissue Location: Expressed in the developing ventral mesencephalon.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Protein shisa-6 homolog, SHISA6