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SHP-2, Human Recombinant | P1560
- SKU:
- 26-P1560-GEN
- Availability:
- Usually shipped in 5 working days
Description
SHP-2, also known as, tyrosine-protein phospatase non-receptor type 11(PTPN11), is a member of the protein tyrosine phosphatase (PTP) family containing two Src homology 2 domains. This protein dephosphorylation tyrosine residues in proteins. It plays a stimulatory role in the activation of the Erk/MAP kinase pathway by receptor tyrosine kinase signaling. Mutations in this protein are a cause of Noonan syndrome as well as acute myeloid leukemia. Recombinant human SHP-2, fused to His-tag at C-terminus, was expressed in an insect cell and purified by using conventional chromatography techniques.
P1560 | SHP-2, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: PTPN11, Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SH-PTP3, BPTP3, CFC, JMML, METCDS, NS1, SHP-2, shp-2, PTP2C, SHPTP2
Alternates names: PTPN11, Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SH-PTP3, BPTP3, CFC, JMML, METCDS, NS1, SHP-2, shp-2, PTP2C, SHPTP2
Taglines: Activates Erk/MAP kinase pathway by receptor tyrosine kinase signaling.
NCBI Gene ID #: 5781
NCBI Gene Symbol: PTPN11
Gene Source: Human
Accession #: Q06124
Recombinant: TRUE
Source: HEK 293 cells
Purity by SDS-PAGE: >90%
Assay: SDS - PAGE
Purity:
Assay #2:
Endotoxin Level: < 1 EU per 1ug of protein (determined by LAL method)
Activity (Specifications/test method): Specific activity is > 400 unit/mg
Biological activity:
Results:
Binding Capacity:
Unit Definition: One unit is defined as the amount of enzyme that hydrolyze 1.0 nmole of pnitrophenyl phosphate (pNPP) per minute at pH 7.5 at 37°C.
Molecular Weight: 69.1 kDa ( His-tag at C-terminus)
Concentration:
Appearance: Liquid
Physical form description: Liquid
Reconstitution Instructions:
Amino acid sequence: aa 602 (1-593 aa)
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
Additional Information
Storage Temperature: |
-20°C |
Shipping: |
Gel Pack |
Shelf Life: |
12 months |