SHP-2, Human Recombinant | P1560

SHP-2, also known as, tyrosine-protein phospatase non-receptor type 11(PTPN11), is a member of the protein tyrosine phosphatase (PTP) family containing two Src homology 2 domains. This protein dephosphorylation tyrosine residues in proteins. It plays a stimulatory role in the activation of the Erk/MAP kinase pathway by receptor tyrosine kinase signaling. Mutations in this protein are a cause of Noonan syndrome as well as acute myeloid leukemia. Recombinant human SHP-2, fused to His-tag at C-terminus, was expressed in an insect cell and purified by using conventional chromatography techniques.

P1560 | SHP-2, Human Recombinant DataSheet

Biomolecule/Target :

Synonyms: PTPN11, Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SH-PTP3, BPTP3, CFC, JMML, METCDS, NS1, SHP-2, shp-2, PTP2C, SHPTP2

Alternates names: PTPN11, Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SH-PTP3, BPTP3, CFC, JMML, METCDS, NS1, SHP-2, shp-2, PTP2C, SHPTP2

Taglines: Activates Erk/MAP kinase pathway by receptor tyrosine kinase signaling.

NCBI Gene ID #: 5781

NCBI Gene Symbol: PTPN11

Gene Source: Human

Accession #: Q06124

Recombinant: TRUE

Source: HEK 293 cells

Purity by SDS-PAGE: >90%

Assay: SDS - PAGE

Purity:

Assay #2:

Endotoxin Level: < 1 EU per 1ug of protein (determined by LAL method)

Activity (Specifications/test method): Specific activity is > 400 unit/mg

Biological activity:

Results:

Binding Capacity:

Unit Definition: One unit is defined as the amount of enzyme that hydrolyze 1.0 nmole of pnitrophenyl phosphate (pNPP) per minute at pH 7.5 at 37°C.

Molecular Weight: 69.1 kDa ( His-tag at C-terminus)

Concentration:

Appearance: Liquid

Physical form description: Liquid

Reconstitution Instructions:

Amino acid sequence: aa 602 (1-593 aa)

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans