SHP099 hydrochloride | B1308

SHP099 is a potent, and selective, SHP2 inhibitor (IC50 = 0.07 μM) and p-ERK modulation in cells (IC₅₀ = 0.250 μM). SHP099 displays dose-dependent pathway inhibition and antitumor activity in xenograft models.

SHP099 is a potent, and selective, SHP2 inhibitor (IC50 = 0.07 μM) and p-ERK modulation in cells (IC₅₀ = 0.250 μM). SHP099 displays dose-dependent pathway inhibition and antitumor activity in xenograft models.

B1308 | SHP099 hydrochloride DataSheet

Alternate Name/Synonyms: 6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine hydrochloride

Appearance: Yellow solid

Formulation: N/A

CAS Number: 1801747-11-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₂₀Cl₃N₅

Molecular Weight: 388.72

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, and selective, SHP2 inhibitor

MDL Number: N/A

PubChem CID: 121241170

SMILES: CC1(CCN(CC1)C2=CN=C(C(=N2)N)C3=C(C(=CC=C3)Cl)Cl)N.Cl

InChi: InChI=1S/C16H19Cl2N5.ClH/c1-16(20)5-7-23(8-6-16)12-9-21-14(15(19)22-12)10-3-2-4-11(17)13(10)18;/h2-4,9H,5-8,20H2,1H3,(H2,19,22);1H

InChi Key: KHQHYRFUYAXWOQ-UHFFFAOYSA-N