Description
SHP099 is a potent, and selective, SHP2 inhibitor (IC50 = 0.07 μM) and p-ERK modulation in cells (IC₅₀ = 0.250 μM). SHP099 displays dose-dependent pathway inhibition and antitumor activity in xenograft models.
SHP099 is a potent, and selective, SHP2 inhibitor (IC50 = 0.07 μM) and p-ERK modulation in cells (IC₅₀ = 0.250 μM). SHP099 displays dose-dependent pathway inhibition and antitumor activity in xenograft models.
B1308 | SHP099 hydrochloride DataSheet
Alternate Name/Synonyms: 6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine hydrochloride
Appearance: Yellow solid
Formulation: N/A
CAS Number: 1801747-11-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₆H₂₀Cl₃N₅
Molecular Weight: 388.72
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent, and selective, SHP2 inhibitor
MDL Number: N/A
PubChem CID: 121241170
SMILES: CC1(CCN(CC1)C2=CN=C(C(=N2)N)C3=C(C(=CC=C3)Cl)Cl)N.Cl
InChi: InChI=1S/C16H19Cl2N5.ClH/c1-16(20)5-7-23(8-6-16)12-9-21-14(15(19)22-12)10-3-2-4-11(17)13(10)18;/h2-4,9H,5-8,20H2,1H3,(H2,19,22);1H
InChi Key: KHQHYRFUYAXWOQ-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |