SHP2 Antibody (Y546) [APR11287G]

SHP2 Antibody (Y546) [APR11287G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SHP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 526-551 amino acids from human SHP2.

Cellular Localisation: Cytoplasm. Nucleus

Molecular Weight: 68011

Clone: Polyclonal

Gene Name: PTPN11

Gene ID: 5781

Function: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573) . Positively regulates MAPK signal transduction pathway (PubMed:28074573) . Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573) . Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669) . Dephosphorylates CDC73 (PubMed:26742426) . Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity) .

Summary: Tissue Location: Widely expressed, with highest levels in heart, brain, and skeletal muscle.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SHP-2, Shp2, SH-PTP3, PTPN11, PTP2C, SHPTP2