Sildenafil citrate | 2872

Sildenafil citrate is a potent, orally active phosphodiesterase 5 (PDE5) inhibitor (IC₅₀ = 4 nM). Inhibition of PDE5 enhances the relaxation of smooth muscle in a range of vascular tissues by prolonging the nitric oxide/cGMP-mediated activation of cGMP-dependent protein kinase (PKG). Sildenafil also acts as a vasodilator and this property has been used to control vascular tone in pulmonary arterial hypertension and high-altitude pulmonary edema associated with altitude sickness.

Sildenafil citrate is a potent, orally active phosphodiesterase 5 (PDE5) inhibitor (IC₅₀ = 4 nM). Inhibition of PDE5 enhances the relaxation of smooth muscle in a range of vascular tissues by prolonging the nitric oxide/cGMP-mediated activation of cGMP-dependent protein kinase (PKG).

2872 | Sildenafil citrate DataSheet

Alternate Name/Synonyms: 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate

Appearance: White solid

Formulation: N/A

CAS Number: 171599-83-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₃₀N₆O₄S.C₆H₈O₇

Molecular Weight: 666.71

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~25 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent phosphodiesterase 5 (PDE5) inhibitor

MDL Number: MFCD09026931

PubChem CID: 62853

SMILES: CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

InChi: InChI=1S/C22H30N6O4S.C6H8O7/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28;7-3(8)1-6(13,5(11)12)2-4(9)10/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChi Key: DEIYFTQMQPDXOT-UHFFFAOYSA-N