Description
Sintilimab (PDCD1/PD1/CD279) Antibody, Monoclonal | 10-919 | Gentaur UK, US & Europe Distribution
Host: N/A
Reactivity: N/A
Homology: N/A
Immunogen: Homo sapiens / PDCD1/PD1/CD279 [Homo sapiens]
Research Area: Drug Analogues
Tested Application: N/A
Application: N/A
Specificiy: N/A
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: >95%
Clonality: Monoclonal
Clone: N/A
Isotype: IgG4-kappa
Conjugate: Unconjugated
Physical State: N/A
Buffer: PBS buffer pH7.5
Concentration: N/A
Storage Condition: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 ˚C for 1-2 weeks. Store at -20 ˚C for 12 months. Store at -80 ˚C for long term storage.
Alternate Name: IBI-308
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: Sintilimab is fully human anti-PD-1 antibody used for tumor immunotherapy. It adopts the IgG4 molecular framework and has its hinge region sequence modified (S228P) . Sindilimum acts as a blocker of programmed death receptor 1 (PD-1) , which can bind to PD-1 molecule on the surface of T cells and release the inhibitory effect of the PD-1 pathway on T cells.