SIRT1 Inhibitor, EX-527 | 1652

A potent SIRT1 inhibitor (IC₅₀ = 38 nM). EX-527 is 200-500-fold more selective for SIRT1 than for SIRT2 or SIRT3. Does not inhibit SIRT4-7, does not inhibit class I/II HDAC activity at concentrations up to 100µM. Enhances p53 acetylation in response to DNA damaging agents.

SIRT1 Inhibitor, EX-527 is a potent SIRT1 inhibitor (IC₅₀ = 38 nM). EX-527 is 200-500-fold more selective for SIRT1 than for SIRT2 or SIRT3. Does not inhibit SIRT4-7, does not inhibit class I/II HDAC activity at concentrations up to 100µM.

1652 | SIRT1 Inhibitor, EX-527 DataSheet

Alternate Name/Synonyms: EX-527, 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

Appearance: White solid

Formulation: N/A

CAS Number: 49843-98-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₃H₁₃ClN₂O

Molecular Weight: 248.71

Cell-Permeable?: Yes

Purity: ≥97% by HPLC

Solubilities: DMSO (20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A SIRT1 inhibitor

MDL Number: MFCD03009471

PubChem CID: 5113032

SMILES: C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N

InChi: InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)

InChi Key: FUZYTVDVLBBXDL-UHFFFAOYSA-N