SIRT6 Antibody (C-term) [APR09972G]

SIRT6 Antibody (C-term) [APR09972G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SIRT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 276-305 amino acids from the C-terminal region of human SIRT6.

Cellular Localisation: Nucleus, nucleoplasm. Note=Predominantly nuclear. Associated with telomeric heterochromatin regions

Molecular Weight: 39119

Clone: Polyclonal

Gene Name: SIRT6

Gene ID: 51548

Function: NAD-dependent protein deacetylase involved in various processes including telomere maintenance and gene expression, and consequently has roles in genomic stability, cell senescence and apoptosis (PubMed:18337721, PubMed:19135889, PubMed:19625767, PubMed:21362626) . Has very weak deacetylase activity and can bind NAD (+) in the absence of acetylated substrate (PubMed:21362626) . Has deacetylase activity towards histone H3K9Ac and H3K56Ac (PubMed:19625767, PubMed:21362626) . Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle (PubMed:19625767) . May also be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance (PubMed:18337721) . Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa- B target genes (PubMed:21362626) . Deacetylation of nucleosomes interferes with RELA binding to target DNA (PubMed:19135889) . Acts as a corepressor of the transcription factor Hif1a to control the expression of multiple glycolytic genes to regulate glucose homeostasis (By similarity) . Required for normal IGF1 serum levels and normal glucose homeostasis (By similarity) . Regulates the production of TNF protein (By similarity) . Has a role in the regulation of life span (By similarity) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: NAD-dependent protein deacetylase sirtuin-6, 351-, Regulatory protein SIR2 homolog 6, SIR2-like protein 6, SIRT6, SIR2L6