Sirtuin 6, human recombinant | 7578

Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards 'Lys-9' and 'Lys-56' of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-.

7578 | Sirtuin 6 human recombinant DataSheet

Biomolecule/Target: Sirtuin 6

Synonyms: SIRT6, NAD-dependent Deacetylase Sirtuin-6; Mono-ADP-ribosyltransferase Sirtuin 6; SIR2-like Protein 6; SIR2L6

Alternates names: SIRT6, NAD-dependent Deacetylase Sirtuin-6; Mono-ADP-ribosyltransferase Sirtuin 6; SIR2-like Protein 6; SIR2L6

Taglines: A NAD-dependent protein deacetylase

NCBI Gene ID #: 6361

NCBI Gene Symbol: CCL17

Gene Source: Human

Accession #: Q92583

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 97%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <0.1 EU/g by LAL method

Activity (Specifications/test method): N/A

Biological activity: Determined by its ability to chemoattract human T-Lymphocytes using a concentration range of 1.0-10.0 ng/ml.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: ~45.0 kDa. Human sirtuin 6 (aa 1-355) is fused at the N-terminus to a His-tag.

Concentration: N/A

Appearance: Liquid

Physical form description: 0.2 m-filtered solution in 55 mM Tris-Cl, pH 8.2, containing 150 mM NaCl.

Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers

Amino acid sequence: N/A