Sivelestat | B2144

Sivelestat (ONO-5046) is a potent neutrophil elastase inhibitor. It acts as a substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC₅₀ = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase). Sivelestat displays >100-fold greater selectivity over pancreatic elastase (IC₅₀ = 5.6 μM). It does not inhibit trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin G even at concentrations as high as 100 μM.

Sivelestat (ONO-5046) is a potent neutrophil elastase inhibitor. It acts as a substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC₅₀ = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase). Sivelestat displays >100-fold greater selectivity over pancreatic elastase (IC₅₀ = 5.6 μM). It does not inhibit trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin G even at concentrations as high as 100 μM.

B2144 | Sivelestat DataSheet

Alternate Name/Synonyms: 2-(2-(4-(pivaloyloxy)phenylsulfonamido)benzamido)acetic acid; ONO-5046

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 127373-66-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₂N₂O₇S

Molecular Weight: 434.46

Cell-Permeable?: Yes

Purity: ≥97% by HPLC

Solubilities: DMSO (>40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent neutrophil elastase inhibitor

MDL Number: MFCD00889071

PubChem CID: 107706

SMILES: CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O

InChi: InChI=1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24)

InChi Key: BTGNGJJLZOIYID-UHFFFAOYSA-N