SKIL (D652) polyclonal Antibody | BS2257

SKIL (D652) polyclonal Antibody | BS2257 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC

Application Range: IHC: 1:50~1:200

Background: Ski-like protein is a protein that in humans is encoded by the SKIL gene. The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB) . In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SKIL (D652) polyclonal Antibody detects endogenous levels of Ski-like protein.

Molecular Weight: ~ 77 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Ski-like protein; Ski-related oncogene; Ski-related protein; SKIL; SNO; SnoN

Immunogen: Synthetic peptide, corresponding to amino acids 630-670 of Human SKIL.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: