SKP1 Antibody | 14-478

SKP1 Antibody | 14-478 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant protein of human SKP1

Research Area: Cell Cycle, Signal Transduction

Tested Application: WB

Application: WB: 1:500 - 1:2000

Specificiy: N/A

Positive Control 1: HeLa

Positive Control 2: 293T

Positive Control 3: U-251MG

Positive Control 4: Mouse brain

Positive Control 5: Mouse heart

Positive Control 6: Rat liver

Molecular Weight: Observed: 15-19kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: SKP1, Cyclin A/CDK2-associated p19, OCP-2, OCP-II, Organ of Corti protein 2, SIII, TCEB1L, Organ of Corti protein II, p19A, SKP1A, EMC19, OCP2, p19skp1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein (s) , and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.