SLC10A2 Antibody | 14-658

SLC10A2 Antibody | 14-658 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 289-348 of human SLC10A2 (NP_000443.1) .

Research Area: Other

Tested Application: WB

Application: WB: 1:500 - 1:2000

Specificiy: N/A

Positive Control 1: HT-29

Positive Control 2: Mouse small intestine

Positive Control 3: Mouse kidney

Positive Control 4: Rat small intestine

Positive Control 5: Rat liver

Positive Control 6: N/A

Molecular Weight: Observed: 38kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: ileal sodium-dependent bile acid transporter, ileal apical sodium-dependent bile acid transporter, OTTHUMP00000040691, NTCP2, ISBT, solute carrier family 10 (sodium/bile acid cotransporter family) , member 2, ASBT, SLC10A2

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM) ; muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG) .