SLC11A1 Antibody (Center) [APR10923G]

SLC11A1 Antibody (Center) [APR10923G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SLC11A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-276 amino acids from the Central region of human SLC11A1.

Cellular Localisation: Membrane; Multi-pass membrane protein

Molecular Weight: 59872

Clone: Polyclonal

Gene Name: SLC11A1

Gene ID: 6556

Function: Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe (2+) and Mn (2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

Summary: Tissue Location: Macrophages; peripheral blood leukocytes, lung, spleen and liver

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IF

Dilution: WB--1:1000 IF--1:10~50

Synonyms: Natural resistance-associated macrophage protein 1, NRAMP 1, Solute carrier family 11 member 1, SLC11A1, LSH, NRAMP, NRAMP1