LBD
SLC12A5 Antibody (N-term) [APR13326G]
- SKU:
- LBD-APR13326G
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- Usually ships in 5 working days
Description
SLC12A5 Antibody (N-term) [APR13326G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This SLC12A5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 5-33 amino acids from the N-terminal region of human SLC12A5.
Cellular Localisation: Membrane; Multi-pass membrane protein.
Molecular Weight: 126184
Clone: Polyclonal
Gene Name: SLC12A5
Gene ID: 57468
Function: Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl (-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl (-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity) . Involved in the regulation of dendritic spine formation and maturation (PubMed:24668262) .
Summary: Tissue Location: Brain specific. Detected in neuronal cells.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P
Dilution: WB--1:4000 WB--1:1000 IHC-P--1:100~500
Synonyms: Solute carrier family 12 member 5, Electroneutral potassium-chloride cotransporter 2, K-Cl cotransporter 2, hKCC2, Neuronal K-Cl cotransporter, SLC12A5, KCC2, KIAA1176