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SLC25A13 polyclonal Antibody | BS7897
- SKU:
- BW-BS7897
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Description
SLC25A13 polyclonal Antibody | BS7897 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human
Application: WB IHC IF
Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Background: Citrin, also known as SLC25A13 (Solute carrier family 25 member 13), ARALAR2 or CTLN2, is a 675 amino acid multi-pass membrane protein that localizes to the inner membrane of the mitochondrion. Expressed in liver, pancreas, kidney, brain, heart and placenta, citrin functions as a calcium-dependent glutamate and aspartate carrier that is thought to play a role in the urea cycle. Citrin, a member of the mitochondrial carrier family, contains three Solcar repeats and four EF-hand domains through which it binds calcium. Defects in the gene encoding citrin are the cause of citrullinemia type 2 (CTLN2) and neonatal intrahepatic cholestasis due to citrin deficiency (NICCD) . CTLN2 is an autosomal recessive disease that results from errors in the urea cycle and is characterized by neuropsychiatric symptoms such as loss of memory, seizures and coma. NICCD, a non-lethal disorder, occurs during infancy and is characterized by low birth weight, reduced bile flow, growth retardation and hepatic fibrosis.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: SLC25A13 polyclonal Antibody detects endogenous levels of SLC25A13 protein.
Molecular Weight: ~ 74 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: ARALAR2; Calcium binding mitochondrial carrier protein Aralar2; Calcium-binding mitochondrial carrier protein Aralar2; Citrin; CMC2_HUMAN; CTLN2; Ctrn; Mitochondrial aspartate glutamate carrier 2; RGD1565889; Slc25a13; Solute carrier family 25 (citrin) member 13; Solute carrier family 25 member 13 (citrin) ; Solute carrier family 25 member 13;
Immunogen: Recombinant full length Human SLC25A13.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: