SLC47A1 Antibody (C-term) [APR10110G]

SLC47A1 Antibody (C-term) [APR10110G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SLC47A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 492-519 amino acids from the C-terminal region of human SLC47A1.

Cellular Localisation: Cell membrane; Multi-pass membrane protein Note=Predominantly localized at the plasma membrane but also found in intracellular organelles

Molecular Weight: 61922

Clone: Polyclonal

Gene Name: SLC47A1

Gene ID: 55244

Function: Solute transporter for tetraethylammonium (TEA), 1-methyl-4- phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent) . Able to transport paraquat (PQ or N, N-dimethyl-4-4'-bipiridinium) ; a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.

Summary: Tissue Location: Expressed in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney (especially found in luminal membranes of the urinary tubules, bile caniculi and brush border membranes) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P-Leica, WB

Dilution: IHC-P-Leica--1:500 WB--1:2000

Synonyms: Multidrug and toxin extrusion protein 1, MATE-1, hMATE-1, Solute carrier family 47 member 1, SLC47A1, MATE1