SLC6A12 polyclonal Antibody | BS60695

SLC6A12 polyclonal Antibody | BS60695 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: BGT-1, also known as sodium- and chloride-dependent betaine transporter, SLC6A12 (solute carrier family 6 member 12) or Na (+) /Cl (-) betaine/GABA transporter, is a 614 amino acid protein. As a multi-pass membrane protein, BGT-1 localizes to liver, heart, skeletal muscle and placenta and is widely distributed in brain. BGT-1 has the typical structure of neurotransmitter transporters, with twelve transmembrane domains and a large extracellular loop between the third and fourth transmembrane domains. BGT-1 transports betaine and GABA, and may have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. BGT-1 is associated with mucus production in asthma, and could affect reversibility of lung function abnormalities in aspirin-intolerant asthma patients. BGT-1 displays significant functional differences from the other members of the GABA transporter family.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SLC6A12 polyclonal Antibody detects endogenous levels of SLC6A12 protein.

Molecular Weight: ~ 69 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Sodium- and chloride-dependent betaine transporter; BGT-1; Na (+) /Cl (-) betaine/GABA transporter; Solute carrier family 6 member 12; SLC6A12

Immunogen: A synthetic peptide corresponding to residues in Human SLC6A12

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A