SLC6A19 Antibody (C-Term) [APR13386G]

SLC6A19 Antibody (C-Term) [APR13386G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SLC6A19 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 544-575 amino acids from human SLC6A19.

Cellular Localisation: Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Colocalizes with ACE2 on the apical membrane of cells lining villi of the jejunum, ileum and on kidney proximal tubules.

Molecular Weight: 71110

Clone: Polyclonal

Gene Name: SLC6A19

Gene ID: 340024

Function: Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells (PubMed:18424768, PubMed:18484095, PubMed:19185582, PubMed:26240152) . This uptake is sodium-dependent and chloride-independent (PubMed:19185582, PubMed:15286788) . Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity (PubMed:19185582, PubMed:18424768) .

Summary: Tissue Location: Robust expression in kidney and small intestine, with minimal expression in pancreas (PubMed:18424768, PubMed:15286787) Also expressed in stomach, liver, duodenum, ileocecum, colon and prostate. Not detected in testis, whole brain, cerebellum, fetal liver, spleen, skeletal muscle, uterus, heart or lung

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Sodium-dependent neutral amino acid transporter B (0) AT1, Solute carrier family 6 member 19, System B (0) neutral amino acid transporter AT1, SLC6A19, B0AT1