SLC8A1 Antibody (Center) [APR32626G]

SLC8A1 Antibody (Center) [APR32626G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This SLC8A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-325 amino acids from the Central region of human SLC8A1.

Cellular Localisation: Cell membrane; Multi-pass membrane protein

Molecular Weight: 108547

Clone: Polyclonal

Gene Name: SLC8A1

Gene ID: 6546

Function: Mediates the exchange of one Ca (2+) ion against three to four Na (+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca (2+) levels and Ca (2+) -dependent cellular processes (PubMed:1374913, PubMed:11241183, PubMed:1476165) . Contributes to Ca (2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca (2+) levels due to release of Ca (2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca (2+) from the cell during the next phase, so that cytoplasmic Ca (2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions.

Summary: Tissue Location: Detected primarily in heart and at lower levels in brain (PubMed:1374913) . Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung (PubMed:1476165)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:500-1:1000

Synonyms: Sodium/calcium exchanger 1, Na (+) /Ca (2+) -exchange protein 1, Solute carrier family 8 member 1, SLC8A1, CNC, NCX1