SLC8A3 Antibody (C-term) [AMM07880G]

SLC8A3 Antibody (C-term) [AMM07880G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SLC8A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 585-614 amino acids of human SLC8A3.

Cellular Localisation: Cell membrane; Multi-pass membrane protein. Perikaryon {ECO:0000250|UniProtKB:P70549}. Cell projection, dendrite {ECO:0000250|UniProtKB:P70549}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P70549}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:S4R2P9}. Cytoplasm, sarcoplasm {ECO:0000250|UniProtKB:S4R2P9}. Cell junction {ECO:0000250|UniProtKB:S4R2P9}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:S4R2P9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:S4R2P9}. Cytoplasm, perinuclear region. Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:S4R2P9}. Note=Detected at neuromuscular junctions. {ECO:0000250|UniProtKB:S4R2P9}

Molecular Weight: 103010

Clone: Polyclonal

Gene Name: SLC8A3

Gene ID: 6547

Function: Mediates the electrogenic exchange of Ca (2+) against Na (+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca (2+) levels and Ca (2+) -dependent cellular processes. Contributes to cellular Ca (2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca (2+) levels due to release of Ca (2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca (2+) from the cell during the next phase, so that cytoplasmic Ca (2+) levels rapidly return to baseline. Contributes to Ca (2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca (2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity) . Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935) . Mediates Ca (2+) efflux from mitochondria and contributes to mitochondrial Ca (2+) ion homeostasis (By similarity) .

Summary: Tissue Location: Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Sodium/calcium exchanger 3, Na (+) /Ca (2+) -exchange protein 3, Solute carrier family 8 member 3, SLC8A3, NCX3