α-SMA polyclonal Antibody | BS70000

α-SMA polyclonal Antibody | BS70000 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC IF

Application Range: WB: 1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background: Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: α-SMA polyclonal Antibody detects endogenous levels of Actin, aortic smooth muscle protein.

Molecular Weight: ~ 45 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ACTA2; AAT6; ACTSA; MYMY5; Actin, aortic smooth muscle; Alpha-actin-2; Cell growth-inhibiting gene 46 protein; alpha-SMA; a-SMA; aSMA; SMA-alpha;

Immunogen: Recombinant full length Human α-SMA.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Regulation of Actin Dynamics,