Description
SMG7 Antibody | 16-018 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SMG7 (NP_963863.2) .
Research Area: Other
Tested Application: WB
Application: WB: 1:200 - 1:2000
Specificiy: N/A
Positive Control 1: Jurkat
Positive Control 2: Mouse testis
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Observed: 127kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: C1orf16, EST1C, SGA56M, protein SMG7, EST1 telomerase component homolog C, EST1-like protein C, breast cancer-associated antigen SGA-56M, ever shorter telomeres 1C, smg-7 homolog, nonsense mediated mRNA decay factor
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD) ; a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.