SMG7 Polyclonal Antibody | E-AB-65287

SMG7 Polyclonal Antibody | E-AB-65287 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: SMG7, C1orf16, EST1C, SGA56M

Application: WB

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Epigenetics and Nuclear Signaling

Background: This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant fusion protein of human SMG7 (NP_963863.2).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method: Affinity purification

Dilution: WB 1:200-1:2000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 122 kDa/127 kDa/131 kDa

Molecular Weight(Observed): 127 kDa