SMG8 Polyclonal Antibody | E-AB-12757

SMG8 Polyclonal Antibody | E-AB-12757 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: ABC 2, ABC2, Amplified in breast cancer gene 2 protein, Chromosome 17 open reading, chromosome 17 open reading frame 71, FLJ10587, Protein smg 8 homolog, protein SMG8, SMG8, SMG8 protein

Application: IHC, ELISA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer

Background: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.

Concentration: 0.3 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human SMG8

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: IHC 1:25-1:100

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A