Smo agonist, SAG dihydrochloride | 2801

SAG hydrochloride is the water-soluble analog of SAG (Cat. No.1939). A cell-permeable Smoothened (Smo) agonist that has shown to induce Hedgehog pathway activation and counteract cyclopamine inhibition of Smo. SAG has been reported to act as an activator at low concentrations, but can inhibit Smo at very high concentrations.

SAG hydrochloride is the water-soluble analog of SAG (Cat. No.1939). A cell-permeable Smoothened (Smo) agonist that has shown to induce Hedgehog pathway activation and counteract cyclopamine inhibition of Smo. SAG has been reported to act as an activator at low concentrations, but can inhibit Smo at very high concentrations.

2801 | Smo agonist, SAG dihydrochloride DataSheet

Alternate Name/Synonyms: N-Methyl-N′-(3-pyridinylbenzyl)-N′-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, dihydrochloride

Appearance: Light yellow solid

Formulation: N/A

CAS Number: 364590-63-6

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₂₈ClN₃OS. 2HCl

Molecular Weight: 562.98

Cell-Permeable?: Y

Purity: ≥98% by HPLC

Solubilities: H2O (~ 25 mg/ml) DMSO (~ 10 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A cell-permeable Smoothened (Smo) agonist

MDL Number: N/A

PubChem CID: 71433770

SMILES: CNC1CCC(CC1)N(CC2=CC=CC(=C2)C3=CC=NC=C3)C(=O)C4=C(C5=CC=CC=C5S4)Cl.O.Cl.Cl

InChi: InChI=1S/C28H28ClN3OS.2ClH.H2O/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20;;;/h2-8,13-17,22-23,30H,9-12,18H2,1H3;2*1H;1H2

InChi Key: IYXUQUYRWPGIQL-UHFFFAOYSA-N