Description
SMYD3 polyclonal Antibody | BS8830 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse
Application: WB IF
Application Range: WB: 1:500~1:2000 IF: 1:50~1:200
Background: SET and MYND domain-containing 3 (SMYD3), a 428 amino acid protein, is a member of an RNA polymerase complex and plays a role in transcriptional regulation. SMYD3 methylates Lys 4 of histone H3, a specific tag for epigenetic transcriptional activation. The SMYD3 protein contains an N-terminal MYND-type zinc finger domain, followed by a SET domain, which shows methyltransferase activity. The presence of the heat-shock protein HSP 90α greatly enhances the methyltransferase activity of SMYD3. SMYD3 is expressed in testis and skeletal muscles and is overexpressed in a majority of colorectal carcinomas (CRCs), hepatocellular carcinomas (HCCs) and breast carcinomas (BCs) . Inhibition of SMYD3 is a potential chemotherapeutic strategy.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: SMYD3 polyclonal Antibody detects endogenous levels of SMYD3 protein.
Molecular Weight: ~ 49kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Histone-lysine N-methyltransferase SMYD3; SET and MYND domain-containing protein 3; Zinc finger MYND domain-containing protein 1; SMYD3; ZMYND1, ZNFN3A1
Immunogen: Recombinant full length Human SMYD3.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Ubiquitin Proteasome,