SMYD5 Antibody (C-term) [APR04427G]

SMYD5 Antibody (C-term) [APR04427G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SMYD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 343-371 amino acids from the C-terminal region of human SMYD5.

Cellular Localisation: N/A

Molecular Weight: 47341

Clone: Polyclonal

Gene Name: SMYD5

Gene ID: 10322

Function: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 to form trimethylated histone H4 lysine 20 (H4K20me3) which represents a specific tag for epigenetic transcriptional repression (By similarity) . In association with the NCoR corepressor complex, is involved in the repression of toll-like receptor 4 (TLR4) -target inflammatory genes in macrophages by catalyzing the formation of H4K20me3 at the gene promoters (By similarity) . Plays an important role in embryonic stem (ES) cell self- renewal and differentiation (By similarity) . Promotes ES cell maintenance by silencing differentiation genes through deposition of H4K20me3 marks (By similarity) . Maintains genome stability of ES cells during differentiation through regulation of heterochromatin formation and repression of endogenous repetitive DNA elements by depositing H4K20me3 marks (PubMed:28951459) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: SET and MYND domain-containing protein 5, 211-, Protein NN8-4AG, Retinoic acid-induced protein 15, SMYD5, RAI15